Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA) Without Inducing Resistance.
Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA) Without Inducing Resistance.
Auteurs : Héloïse Côté [Canada] ; André Pichette [Canada] ; François Simard [Canada] ; Marie-Eve Ouellette [Canada] ; Lionel Ripoll [Canada] ; Mouadh Mihoub [Canada] ; Doria Grimard [Canada] ; Jean Legault [Canada]Source :
- Frontiers in microbiology [ 1664-302X ] ; 2019.
Abstract
New options are urgently needed for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Balsacone C is a new dihydrochalcone extracted from Populus balsamifera that has been reported previously as being active against Staphylococcus aureus. Here, we evaluate the antibacterial activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were obtained from hospitalized patients; these isolates were then characterized for their resistance. Most of these MRSA (>85%) were resistant to penicillin, amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, clindamycin, erythromycin, and cefoxitin as well as being sensitive to linezolid, trimethoprim/sulfamethoxazole, rifampicin, and gentamicin. When tested against all MRSA isolates and various gram-positive bacteria, the antibacterial activity of balsacone C produced a MIC of 3-11.6 mg/mL. We observed no resistant isolates of MRSA (against balsacone C) even after 30 passages. Microscopy fluorescence showed that bacteria cell membrane integrity was compromised by low concentrations of balsacone C. Scanning electron microscope (SEM) confirmed balsacone C-provoked changes in the bacterial cell membrane and we find a dose-dependent release of DNA and proteins. This loss of cellular integrity leads to cell death and suggests a low potential for the development of spontaneous resistance.
DOI: 10.3389/fmicb.2019.02341
PubMed: 31681206
PubMed Central: PMC6804428
Affiliations:
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Andre" uniqKey="Pichette A" first="André" last="Pichette">André Pichette</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Simard, Francois" sort="Simard, Francois" uniqKey="Simard F" first="François" last="Simard">François Simard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Ouellette, Marie Eve" sort="Ouellette, Marie Eve" uniqKey="Ouellette M" first="Marie-Eve" last="Ouellette">Marie-Eve Ouellette</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Ripoll, Lionel" sort="Ripoll, Lionel" uniqKey="Ripoll L" first="Lionel" last="Ripoll">Lionel Ripoll</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mihoub, Mouadh" sort="Mihoub, Mouadh" uniqKey="Mihoub M" first="Mouadh" last="Mihoub">Mouadh Mihoub</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Grimard, Doria" sort="Grimard, Doria" uniqKey="Grimard D" first="Doria" last="Grimard">Doria Grimard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Microbiologie, Complexe Hospitalier de la Sagamie, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire de Microbiologie, Complexe Hospitalier de la Sagamie, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Legault, Jean" sort="Legault, Jean" uniqKey="Legault J" first="Jean" last="Legault">Jean Legault</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in microbiology</title><idno type="ISSN">1664-302X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">New options are urgently needed for the treatment of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections. Balsacone C is a new dihydrochalcone extracted from <i>Populus balsamifera</i> that has been reported previously as being active against <i>Staphylococcus aureus</i>. Here, we evaluate the antibacterial activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were obtained from hospitalized patients; these isolates were then characterized for their resistance. Most of these MRSA (>85%) were resistant to penicillin, amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, clindamycin, erythromycin, and cefoxitin as well as being sensitive to linezolid, trimethoprim/sulfamethoxazole, rifampicin, and gentamicin. When tested against all MRSA isolates and various gram-positive bacteria, the antibacterial activity of balsacone C produced a MIC of 3-11.6 mg/mL. We observed no resistant isolates of MRSA (against balsacone C) even after 30 passages. Microscopy fluorescence showed that bacteria cell membrane integrity was compromised by low concentrations of balsacone C. Scanning electron microscope (SEM) confirmed balsacone C-provoked changes in the bacterial cell membrane and we find a dose-dependent release of DNA and proteins. This loss of cellular integrity leads to cell death and suggests a low potential for the development of spontaneous resistance.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31681206</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-302X</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Frontiers in microbiology</Title><ISOAbbreviation>Front Microbiol</ISOAbbreviation></Journal><ArticleTitle>Balsacone C, a New Antibiotic Targeting Bacterial Cell Membranes, Inhibits Clinical Isolates of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Without Inducing Resistance.</ArticleTitle><Pagination><MedlinePgn>2341</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmicb.2019.02341</ELocationID><Abstract><AbstractText>New options are urgently needed for the treatment of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections. Balsacone C is a new dihydrochalcone extracted from <i>Populus balsamifera</i> that has been reported previously as being active against <i>Staphylococcus aureus</i>. Here, we evaluate the antibacterial activity of balsacone C against MRSA. Thirty-four (34) MRSA isolates were obtained from hospitalized patients; these isolates were then characterized for their resistance. Most of these MRSA (>85%) were resistant to penicillin, amoxicillin/clavulanic acid, ciprofloxacin, moxifloxacin, levofloxacin, clindamycin, erythromycin, and cefoxitin as well as being sensitive to linezolid, trimethoprim/sulfamethoxazole, rifampicin, and gentamicin. When tested against all MRSA isolates and various gram-positive bacteria, the antibacterial activity of balsacone C produced a MIC of 3-11.6 mg/mL. We observed no resistant isolates of MRSA (against balsacone C) even after 30 passages. Microscopy fluorescence showed that bacteria cell membrane integrity was compromised by low concentrations of balsacone C. Scanning electron microscope (SEM) confirmed balsacone C-provoked changes in the bacterial cell membrane and we find a dose-dependent release of DNA and proteins. This loss of cellular integrity leads to cell death and suggests a low potential for the development of spontaneous resistance.</AbstractText><CopyrightInformation>Copyright © 2019 Côté, Pichette, Simard, Ouellette, Ripoll, Mihoub, Grimard and Legault.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Côté</LastName><ForeName>Héloïse</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pichette</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simard</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ouellette</LastName><ForeName>Marie-Eve</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ripoll</LastName><ForeName>Lionel</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mihoub</LastName><ForeName>Mouadh</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimard</LastName><ForeName>Doria</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratoire de Microbiologie, Complexe Hospitalier de la Sagamie, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Legault</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Recherche sur la Boréalie, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Microbiol</MedlineTA><NlmUniqueID>101548977</NlmUniqueID><ISSNLinking>1664-302X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MRSA</Keyword><Keyword MajorTopicYN="N">Populus balsamifera</Keyword><Keyword MajorTopicYN="N">Staphylococcus aureus</Keyword><Keyword MajorTopicYN="N">antibiotic</Keyword><Keyword MajorTopicYN="N">balsacone</Keyword><Keyword MajorTopicYN="N">buds</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>03</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31681206</ArticleId><ArticleId IdType="doi">10.3389/fmicb.2019.02341</ArticleId><ArticleId 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Francois" uniqKey="Simard F" first="François" last="Simard">François Simard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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